Here are how the two teams look ahead of the match at the Jan Breydel Stadium.
Ole Gunnar Solskjaer has taken the opportunity to rest players after making six changes to the side that beat Chelsea 2-0 on Monday.
Man United: Romero, Dalot, Lindelof, Maguire, Shaw, Williams, Mata, Matic, Andreas, Lingard & Martial
It looks as if United will operate with a back five, meanwhile January signing Odion Ighalo is on the bench.
For Club Brugge there are starts for former Liverpool goalkeeper Simon Mignolet and Percy Tau, who is on loan from Brighton and Hove Albion.